Technology Innovations

Posts Tagged ‘Biomarkers


Bangalore-based PathShodh Healthcare, a startup at the Entrepreneurship Centre of the Indian Institute of Science, has developed a hand-held device to measure eight vital parameters for diabetes, kidney failure, chronic anaemia, and malnutrition.

The device, called anuPath, has been developed by Dr. Vinay Kumar along with Professor Navakanta Bhat of Indian Institute of Science and a friend, Gautam Sharma.

According to a recent International Diabetes Federation (IDF) report, diabetes currently affects over 425 million people worldwide, and the figure is expected to reach 629 million by 2045. With 73 million diabetics, India ranks second in the world after China.

People with diabetes have an increased risk of developing a number of serious health problems. Consistently high blood glucose levels can lead to serious diseases affecting the heart and blood vessels, eyes, kidneys, nerves and teeth. In addition, people with diabetes also have a higher risk of developing infections, says the IDF report.

Currently, anuPath can test for hemoglobin, HbA1C, glycated albumin, blood glucose, serum albumin, microalbuminuria, urine ACR, and urine creatinine. It will be extendable to other markers (glycated albumin, serum creatinine, serum bilirubin, etc.) in the future. It works on a non-enzymatic- and non-antibody-based electrochemical biosensing technology. The measurement is done on electrochemical disposable test strips that contain a membrane infused with patented sensing substances. For each biomarker there is a separate disposable strip. When the user places the required sample on the electrochemical disposable test strip, anuPath detects the electrochemical outcomes and the deciphered results are displayed on the digital monitor within a minute. This enables the patient to get a comprehensive report of the status of the disease, which is essential in disease management. Read full research paper.

Presently, it can store one lakh patient reports, making it easier to share with doctors. With one international patent and eight in process, anuPath costs Rs. 50,000. The team is working on a cost effective model of about Rs. 5,000 – Rs. 10,000 for individual users to use it at home. Read more


A spoonful of yogurt could soon offer a cheap and simple way to screen for colorectal cancer. MIT Professor Sangeeta Bhatia is working to replace costly and uncomfortable colonoscopies and MRIs with a helping of yogurt followed by a urine test—a cheap method that could improve the early diagnosis of colorectal cancer.

Bhatia is developing synthetic molecules that can be introduced into the body via yogurt, and will interact with cancer in a way that produces telltale biomarkers. These molecules can then be detected easily when passed in urine.

Bhatia previously developed nanoparticles that find their way to tumors, and are then broken into smaller pieces by enzymes produced by the cancer. The broken up particles are small enough to be collected and concentrated by the kidneys, after which they are excreted. The first iteration of the technique involved the use of lab instruments to analyze urine and find the telltale markers. Now Bhatia has developed a paper-based urine test—like the one you’d use for pregnancy. So far this test has been demonstrated in mice for colorectal cancer and liver fibrosis. Read more


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